Cardiac Magnetic Resonance for evaluating early outcomes of stem cell therapy in non-ischemic dilated cardiomyopathy
نویسندگان
چکیده
Methods Thirty seven patients with non-ischemic DCM underwent intracoronary injection of autologous bone marrow derived mononuclear cells. All patients gave informed consent for stem cell therapy and CMR studies. Mononuclear cells separated from aspirated bone marrow were injected into right and left coronary arteries. All patients had baseline CMR, while 10 underwent followup CMR (1.5 T, Magnetom Avanto, Siemens, Germany). Short axis cine-CMR was performed from the base to the apex of left ventricle (slice thickness 6-8 mm, interslice gap 2 mm). Images were analyzed for change in left ventricular (LV) and right ventricular (RV) ejection fraction (EF), corresponding ventricular volumes [enddiastolic (EDV), end-systolic (ESV) and stroke volume (SV)], and LV mass. Wilcoxon signed rank test was used to compare preand post-CMR results. Mann-Whitney U test was used to correlate change in functional class and CMR results
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